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The Effect of a Single Dose of Metrifonate on Schistosoma Haematobium Infection in Egyptian School Children^*

Aziz El Kholy, Samir Boutros, Fathy Tamara, Kenneth S. Warren AND Adel A. F. Mahmoud

Biomedical Research Center for Infectious Diseases, Cairo, Egypt
The Rockefeller Foundation, New York, New York 10036
Division of Geographic Medicine, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland, Ohio 44106

Egyptian school children infected with Schistosoma haematobium and treated with a single dose of metrifonate, 10 mg/kg body weight, had a marked reduction in urine egg counts reaching 90% during a 30-week follow-up. While cure rate was higher among lightly infected persons, percentage reduction in egg counts was greater among the heavily infected. After a summer period of probable high risk exposure reinfection rate in those children who were treated and cured was 4.7% as compared to 6% in previously uninfected children.

Accepted for publication May 25, 1984.

^* This study was supported by grants from the National Institutes of Health (Agreement No. 03050-N) and The Edna McConnell Clark Foundation.

Address reprint requests to: Dr. Adel Mahmoud, Division of Geographic Medicine, University Hospitals, Cleveland, Ohio 44106.