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Am. J. Trop. Med. Hyg., 33(6), 1984, pp. 1078-1083
Copyright © 1984 by The American Society of Tropical Medicine and Hygiene

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Enhancement of the Autologous Mixed Lymphocyte Reaction in Patients with Chagas' Heart Disease*

Aldina P. Barral, M. Barral-Netto, A. Rassi, J. M. Rezende AND R. d'A. Gusmaão
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, Department of Medicine, Federal University of Goias, Goiania-GO, Brazil, and Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), 21040-Rio de Janeiro, R.J., Brazil

Autologous mixed lymphocyte reactions (AMLR) were studied in 18 individuals chronically infected with Trypanosoma cruzi. These individuals were further classified into three clinical groups: the asymptomatic indeterminate form (n = 5); the mega disease form (n = 5); and the cardiomyopathy form (n = 8). While patients with mega disease showed a normal proliferative response when compared with normal controls, the indeterminate group showed a lowered response in sharp contrast with the heart disease group, which presented a very high proliferative response to autologous non-T cells. These abnormal AMLR represent direct evidence for an immunoregulatory malfunction which may be involved in the inflammatory cardiac damage in chronic Chagas' disease.

Accepted for publication June 1, 1984.


* Address reprint requests to: Dr. Aldina Barral, Hospital Prof. Edgard Santos, Laboratório de Imunologia, R. João das Botas, s/n, 40.000-Salvador-Bahia, Brazil.






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Copyright © 1984 by the American Society of Tropical Medicine and Hygiene.