AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 33(5), 1984, pp. 827-834
Copyright © 1984 by The American Society of Tropical Medicine and Hygiene

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Specific and Non-Specific Lymphocyte Blastogenic Responses in Individuals Infected with Trypanosoma Cruzi*

Renato d'A. Gusmão{dagger},{ddagger}, Anis Rassi§, Joffre M. Rezende§ AND Franklin A. Neva{ddagger}
{ddagger} Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205
§ Department of Medicine, Federal University of Goiás, 74000 Goiânia, GO-Brazil

Lymphocyte blastogenic response to various parasite-specific and non-parasite antigens was measured in 31 Trypanosoma cruzi-infected individuals representing the indeterminate, megadisease and cardiomyopathy forms of Chagas' disease. The non-parasite antigens and mitogens stimulated responses in the peripheral blood mononuclear cell (PBMC) cultures of the infected individuals to levels not different than the stimulation seen in PBMC of the normal control group (n = 10). The cell culture antigen (CC-Ag) derived from trypomastigote-amastigote forms of T. cruzi and the epimastigote antigen (EPI-Ag) elicited a strong response among all infected individuals in contrast to virtually no response among the normal controls. Comparisons among the individuals with T. cruzi infection stimulated with EPI-Ag showed no significant difference between the clinical groups. However, stimulus with CC-Ag showed the megadisease group response to be greater than the response of the indeterminate group, but not different than that of the cardiomyopathy group. The possible biological implications of these findings are discussed.

Accepted for publication September 9, 1983.


* Supported in part by PAHO/AMRO 8901, and by the Brazilian National Research Council (C.N.Pq.).


{dagger} Present address: OPS/OMS, Apartado 2171, Maracay, Venezuela.






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Copyright © 1984 by the American Society of Tropical Medicine and Hygiene.