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Am. J. Trop. Med. Hyg., 33(5), 1984, pp. 800-804
Copyright © 1984 by The American Society of Tropical Medicine and Hygiene

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Observations on Local Heat Treatment for Cutaneous Leishmaniasis

Franklin A. Neva*, Eskild A. Petersen*, Roland Corsey{dagger}, D. Huberto Bogaert{ddagger} AND Denise Martinez{ddagger}
* National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases and Laboratory of Clinical Investigation
{dagger} Biomedical Engineering and Instrumentation Branch, Applied Clinical Engineering Section, National Institutes of Health, Bethesda, Maryland 20205
{ddagger} Instituto Dermatologico, Dominican Republic

Local heat treatment was tested and found effective in three patients with diffuse cutaneous leishmaniasis (DCL), a form of disease poorly responsive to the usual chemotherapy. A water bath that circulated water through a pad wrapped around the lesion provided a temperature of 39°C to 41°C for a cumulative time of at least 20 hours, over a period of several days. In the DCL patients beneficial effect of heat treatment was documented by pre- and post-treatment biopsies and cultures. Several other patients with ordinary cutaneous leishmaniasis did not respond to the same form of treatment. It was concluded that different strains and/or species of leishmanial parasites vary in their sensitivity to elevated temperature. While local heat treatment may be curative in certain cases of cutaneous leishmaniasis, such therapy is still experimental and should be monitored by quantitative parasitological studies to document its usefulness.

Accepted for publication January 16, 1984.




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M. CALVOPINA, E. A. GOMEZ, H. SINDERMANN, P. J. COOPER, and Y. HASHIGUCHI
RELAPSE OF NEW WORLD DIFFUSE CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA (LEISHMANIA) MEXICANA AFTER MILTEFOSINE TREATMENT
Am J Trop Med Hyg, December 1, 2006; 75(6): 1074 - 1077.
[Abstract] [Full Text] [PDF]


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Copyright © 1984 by the American Society of Tropical Medicine and Hygiene.