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Evaluation of the 4-Pyridinemethanol WR 180,409 (Enpiroline) in the Treatment of Induced Plasmodium Falciparum Infections in Healthy, Non-Immune Subjects^*

WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case.

Accepted for publication March 8, 1984.

^* The subjects in these studies were United States Army personnel at the United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, as well as civilians from the Washington, D.C. area. The studies were governed by the principles, policies, and rules for medical volunteers as established by Army Regulation 70-25 and the Declaration of Helsinki.

The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense.