AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 33(4), 1984, pp. 544-547
Copyright © 1984 by The American Society of Tropical Medicine and Hygiene

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In Vitro Infectivity of Irradiated Plasmodium Berghei Sporozoites to Cultured Hepatoma Cells

Cynthia I. Sigler, Pamela Leland AND Michael R. Hollingdale
Biomedical Research Institute, 12111 Parklawn Drive, Rockville, Maryland 20852

The invasion of gamma-irradiated Plasmodium berghei sporozoites into cultured hepatoma cells and their transformation into trophozoites was similar to invasion and transformation of non-irradiated sporozoites. However, trophozoites from irradiated sporozoites did not further develop into schizonts, but persisted within the cells for up to 3 days. Sporozoite surface protective antigen was present in trophozoites from irradiated and non-irradiated sporozoites, suggesting that hepatocyte antigen processing may contribute to the induction of anti-malarial immunity.

Accepted for publication December 21, 1983.




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Copyright © 1984 by the American Society of Tropical Medicine and Hygiene.