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Am. J. Trop. Med. Hyg., 33(3), 1984, pp. 420-424
Copyright © 1984 by The American Society of Tropical Medicine and Hygiene

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A Monoclonal Antibody to Surface Antigens on Microfilariae of Brugia malayi Reduces Microfilaremia in Infected Jirds*

M. Canlas, A. Wadee, L. Lamontagne AND W. F. Piessens
Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

A monoclonal antibody to surface antigens of Brugia malayi microfilariae promotes the adherence of peripheral blood cells to microfilariae in vitro and reduces microfilaremia in vivo. The antibody reacts with epitopes present on two stage-specific antigens with estimated molecular weights of 70,000 and 75,000 daltons.

Accepted for publication December 12, 1983.


* Supported in part by Research Grant AI 16479 from the National Institutes of Health, Bethesda, Maryland, and by the Rockefeller Foundation, and by the Filariasis Component of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.






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Copyright © 1984 by the American Society of Tropical Medicine and Hygiene.