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The Response of Kenyan Kala-Azar to Treatment with Sodium Stibogluconate

P. H. Rees^*, P. A. Kager^*,,, B. T. Wellde AND W. T. Hockmeyer

^* Department of Medicine, University of Nairobi
Medical Research Centre, Nairobi
Walter Reed Project, Kenya Medical Research Institute, Nairobi, Kenya

Of 16 patients with kala-azar treated with sodium stibogluconate (0.1 ml/kg body weight a day), one died on the 12th day of treatment and nine were cured by a 30-day course, although two subsequently relapsed. Extending the course cured a further five patients, and in one patient allopurinol was used in addition before a cure was achieved. Clinical and hematological recovery began within a few days of the start of treatment, but parasites continued to be seen in splenic aspirates for 3 weeks or more.

Accepted for publication October 26, 1983.