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Replication of Rift Valley Fever Virus in the Sand Fly Lutzomyia Longipalpis^*

Rift Valley fever virus was shown to replicate in Lutzomyia longipalpis after intrathoracic inoculation. Viral titers peaked at approximately 4 days postinoculation [mean titer = 10^4.0 plaque forming units (PFU)] and remained relatively constant through day 7. A minimum of 6 of 326 sand flies transmitted virus by bite to susceptible hamsters after 5–9 days of extrinsic incubation. Viral titers of sand flies exposed per os declined steadily through day 9. None of 378 flies that had ingested approximately 10^4.0 PFU of virus transmitted virus when refed on susceptible hamsters.

Accepted for publication October 6, 1983.

^* In conducting the research described in this report, the investigators adhered to the "Guide for the Care and Use of Laboratory Animals," as promulgated by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council. The facilities are fully accredited by the American Association for Accreditation of Laboratory Animal Care.

The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense.

During these investigations Michael J. Turell was a Research Associate sponsored by the National Research Council.

Address reprint requests to: Alfred L. Hoch, Department of Arboviral Entomology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701.