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Lack of Transplacental Infection with Scrub Typhus Organisms in Laboratory Mice^*

Akira Shirai, Teik Chye Chan, Elsie Gan AND Michael G. Groves

Female mice were inoculated with either a virulent or avirulent strain of Rickettsia tsutsugamushi before (1 month and 1 week) or after (approximately 10 days) impregnation. From each group, two pregnant mothers were killed on day 20 post-impregnation, and fetuses and placentas were examined for rickettsiae. Organisms were isolated from 80% of placentas but not from the fetuses. Immediately following parturition, litters from 50% of the infected mothers were exchange with litters from uninfected mothers. In all cases, no scrub typhus rickettsiae were found in the litters examined on days 1, 7, and 30 postpartum, and no antibody was found in sera collected 1 and 2 months postpartum.

Accepted for publication September 2, 1983.

^* This study was supported by Research Grant No. DAMD17-81-G-9481 from U.S. Army Medical Research and Development Command, Fort Detrick, Maryland 21701.

In conducting the research described in this report, the investigators adhered to the "Guide for the Care and Use of Laboratory Animals," prepared by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council (DHEW Publication No. [NIH] 78-23, revised 1978).

Address reprint requests to: Commander, U.S. Army Medical Research Unit, Institute for Medical Research, Kuala Lumpur, Malaysia.

Present address: Headquarters, U.S. Army Medical Research and Development Command, Fort Detrick, Frederick, Maryland 21701.

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