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Cerebral Cysticercosis: Treatment with Praziquantel

Report of Two Cases^*

Kurt Markwalder, Klaus Hess, Anton Valavanis AND Felix Witassek^||

Medical Policlinic, Department of International Medicine
Neurological Clinic
Institute of Radiodiagnostic
^< Institute of Parasitology, University of Zurich, Zurich, Switzerland

Two patients with cerebral cysticercosis are described: one with a long-standing infection with multiple intracerebral calcifications, and one who had become infected only recently. Treatment with praziquantel 50 mg/kg body weight daily for 14 days resulted in clinical and radiological improvement in the first patient, although she obviously still harbored a number of viable non-calcified parasites. The second patient was completely cured by the same praziquantel regimen. Both patients needed temporary corticosteroid treatment to suppress development of intracranial hypertension. Computerized tomographic scanning and regular measurement of serum antibody titers against cysticercal and echinococcal antigen seem appropriate methods for follow-up of the effect of chemotherapy.

Accepted for publication August 23, 1983.

^* Address reprint requests to: Dr. K. Markwalder, Medical Policlinic, Department of Internal Medicine, University Hospital, CH-8091 Zurich, Switzerland.