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Studies of Trypanosoma Cruzi Clones in Inbred Mice

II. Course of Infection of C57BL/6 Mice with Single-Cell-Isolated Stocks^*

Miriam Postan, James P. McDaniel AND James A. Dvorak

A study of the course of parasitemia and mortality of C57BL/6 mice infected with the Trypanosoma cruzi Sylvio-X10 strain and two single-cell-isolate clones of the strain confirms our previous report on the existence of intra-strain subpopulations differing in their pathogenicity for inbred mice. In contrast to the generally accepted pattern of mouse strain susceptibility, C57BL/6 mice are more susceptible than C3H/HeN mice when infected with the Sylvio-X10 isolates. In addition, sex-related differences in susceptibility occurred depending upon the strain of the mouse and parasite isolate used. These data infer an interplay of host and parasite genetic factors influencing the outcome of a mouse infection with T. cruzi.

Accepted for publication September 22, 1983.

^* Address reprint requests to: Dr. James A. Dvorak, National Institutes of Health, NIAID, LPD, Building 5, Room 112, Bethesda, Maryland 20205.

This work was supported in part by a Research Training Grant from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.