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Am. J. Trop. Med. Hyg., 32(6), 1983, pp. 1435-1444
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

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Viruses Isolated from Panamanian Sloths*

Charles Seymour{dagger}, Pauline H. Peralta AND G.Gene Montgomery
Gorgas Memorial Laboratory, P.O. Box 935, APO Miami, Florida 34002, and Smithsonian Tropical Research Institute, P.O. Box 2072, Balboa, Panamá

Seven virus strains were isolated in Vero cells from whole blood samples from 80 wild-caught sloths, Bradypus variegatus and Choloepus hoffmanni, from Central Panamá. Four strains of at least two different serotypes are related to Changuinola virus; two of these were associated with prolonged or recrudescent viremias. One strain is an antigenic subtype of Punta Toro virus, and another, described here as Bradypus-4 virus, is a new, antigenically ungrouped virus. A second new virus from sloths, Utive virus, forms an antigenic complex within the Simbu serogroup with Utinga and Pintupo viruses. Tests on sequential plasma samples from radio-marked free-ranging sloths and from recently captured animals maintained in captivity showed that both species develop neutralizing antibodies following naturally acquired virus infections. Antibodies against the Changuinola and Simbu serogroup viruses are widespread in both sloth species and are especially prevalent in Choloepus, but are virtually absent in all other wild vertebrate species tested.

Accepted for publication May 9, 1983.


* This study was supported in part by USPHS National Institutes of Health Grants No. AI-02984 and AI 11889, by the Martin Hansen Fund and Fluid Research Fund grants from the Smithsonian Institution, and by AID Contract No. TA-3-1134.

Address reprint requests to: Dr. Pauline H. Peralta, Gorgas Memorial Laboratory, P.O. Box 935, APO Miami, Florida 34002.


{dagger} Present address: Microbiology Division, St. Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105.






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Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.