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The Etiology of Acute Viral Hepatitis in an Endemic Area of Hepatitis A and B^*

Yun-Fan Liaw, Chia-Ming Chu, Miau-Ju Huang, Tong-Jong Chen AND Deng-Yn Lin

Liver Unit
Department of Pathology, Chang-Gung Memorial Hospital, Lin-Kou Medical Center, Taipei, Taiwan, Republic of China

To understand the etiology of acute viral hepatitis in an endemic area of hepatitis A and B, serological markers of hepatitis were studied by radioimmunoassay in a consecutive series of 145 adult patients with biopsy-verified acute viral hepatitis. Seven (4.8%) were classified as hepatitis A, 92 (63.5%) as hepatitis B, and 46 (31.7%) as hepatitis non-A, non-B. Most persons with severe acute viral hepatitis were hepatitis B antigen (HBsAg)-positive, and hepatitis A appears to play a minor role if any. The evidence also implies that non-B hepatitis may have occurred intercurrently in chronic HBsAg carriers in this area.

Accepted for publication December 9, 1982.

^* Address reprint requests to: Yun-Fan Liaw, M.D., Chief, Liver Unit, Chang-Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei, Taiwan, Republic of China.