HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schantz, P. M. Articles by Rausch, R. L. Search for Related Content PubMed PubMed Citation Articles by Schantz, P. M. Articles by Rausch, R. L.

Serologic Tests for Diagnosis and Post-Treatment Evaluation of Patients with Alveolar Hydatid Disease (Echinococcus Multilocularis)

P. M. Schantz^*, J. F. Wilson, S. P. Wahlquist^*, L. P. Boss AND R. L. Rausch

^* Helminthic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333
Department of Surgery, Box 7-741, Alaska Native Medical Center, Anchorage, Alaska 99510
Division of Animal Medicine, School of Medicine, University of Washington, Seattle, Washington 98195

The indirect hemagglutination (IHA) and immunoelectrophoresis (IEP) tests were used for diagnosis and follow-up evaluation of 17 patients with alveolar hydatid disease caused by Echinococcus multilocularis. Follow-up periods ranged from 2 to 22 years. At the time of diagnosis 16 (94%) patients' sera gave IHA titers 1:128. Serum specimens from 13 patients were examined by IEP; nine (69%) revealed the arc 5, and three of the four arc 5-negative sera revealed one or more non-characterized bands. Titers declined markedly during the first year following radical surgical resection of the larval lesions; in three cases clinical evidence of recurrence was preceded by rising serologic titers. Antibody has persisted at high levels in nonresected patients treated continuously with high doses of mebendazole.

Accepted for publication April 11, 1983.