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Differences in Hepatic Fibrosis in Icr, C3H, and C57BL/6 Mice Infected with Schistosoma Mansoni^*

Allen W. Cheever, Michael A. Dunn, David A. Dean AND Rodeney H. Duvall

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205
Department of Gastroenterology, Division of Medicine, Walter Reed Army Institute of Research, Washington, D.C. 20012 and Department of Medicine, Uniformed Services University School of Medicine, Bethesda, Maryland 20814
Immunoparasitology Branch, Naval Medical Research Institute, Bethesda, Maryland 20814

The collagen content of the liver, measured as hepatic hydroxyproline, was examined for a period of up to 52 weeks following Schistosoma mansoni infection. Hepatic fibrosis was much more marked in S. mansoni-infected mice of an outbred ICR strain than in C57BL/6J mice, while C3H/HeN mice occupied an intermediate position. The marked difference in hepatic fibrosis in ICR and C57BL/6J mice correlated with more rapid in vitro synthesis of collagen by the livers of infected ICR mice. Strains of mice exhibiting high and low levels of fibrosis provide an excellent tool for examining mechanisms of murine schistosomal hepatic fibrosis and its genetic regulation.

Accepted for publication April 21, 1983.

^* This work was partially supported by the Naval Medical Research and Development Command, Work Unit No. MR041.05.0023, the Office of Naval Research Contract No. N00014.76.C0146, and by a research grant from the Edna McConnell Clark Foundation. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Department of Defense.