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Am. J. Trop. Med. Hyg., 32(6), 1983, pp. 1344-1346
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

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Safety and Toxicity of Oxamniquine in the Treatment of Schistosoma Mansoni Infections, with Particular Reference to Electroencephalographic Abnormalities

Sigmund Krajden, Jay S. Keystone AND Cathie Glenn
Tropical Disease Unit, Department of Medicine, Toronto General Hospital, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada

Thirty-seven patients infected with Schistosoma mansoni were treated with oxamniquine. All were cured. The only significant adverse reaction was the development of abnormal electroencephalographic (EEG) findings in 6 (17.6%) of 34 patients whose pretreatment EEG was normal. Management of patients, with particular reference to the EEG abnormalities, is discussed.

Accepted for publication April 29, 1983.






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Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.