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Successful Praziquantel Treatment of Paragonimiasis Following Bithionol Failure

A Case Report^*

Richard J. Johnson, Steven B. Dunning, Barbara H. Minshew AND Elaine C. Jong

Department of Medicine
Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195
Sea-Mar Community Health Clinic, Seattle, Washington

A patient from Southeast Asia with cough and hemoptysis was documented to have pulmonary paragonimiasis. Initial treatment with bithionol failed. The patient was then treated with praziquantel 75 mg/kg body weight a day for 2 days under an investigational protocol. Subsequent follow-up studies showed clinical improvement and indicated parasitologic cure. A concurrent asymptomatic Clonorchis infection was also cured following praziquantel treatment. Side effects were minor.

Accepted for publication May 6, 1983.

^* This study was supported in part by grants from the Rockefeller Foundation and by Infectious Diseases Training Grant AI 07044. The laboratory studies were supported in part by the Seattle Public Health Hospital. Praziquantel was donated by Miles Pharmaceuticals.

Address reprint requests to: Elaine C. Jong, M.D., Division of Infectious Diseases, RM-16, School of Medicine, University of Washington, Seattle, Washington 98195.