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Anti-Sporozoite Antibodies Induced by Natural Infection^*

Pramuan Tapchaisri, Yaowamarn Chomcharn, Chaiya Poonthong, Achara Asavanich, Supatra Limsuwan, Orvadee Maleevan, Savanat Tharavanij AND Tranakchit Harinasuta^||

Department of Microbiology and Immunology
Department of Medical Entomology
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University
^|| Malaria Division, Ministry of Public Health, Bangkok, Thailand

Serum samples from 120 individuals living in a malaria-endemic area, 31 patients with Plasmodium falciparum infection, and 58 healthy blood donors were tested for antibodies against P. falciparum and P. vivax sporozoites. Specific antibodies were determined by the circumsporozoite precipitation (CSP) reaction and indirect immunofluorescent (IFA) tests for IgG and IgM antibodies. It was found that a high proportion of adults living in the endemic area had IFA anti-sporozoite antibodies, usually IgG. Children and healthy donors were either negative or had low antibody titers. A positive correlation was found between IgG antibody titers against P. falciparum sporozoites and those against P. vivax sporozoites. CSP reactivity was demonstrated in 5 of 31 sera from patients with falciparum malaria, and was always associated with a high level of IFA antibodies. The anti-sporozoite antibodies were found to be stage- and species-specific.

Accepted for publication April 26, 1983.

^* This investigation was supported by the U.S. Agency for International Development Contract No. DPE-0453-C-00-2002-00 through the New York University School of Medicine, and the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.

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