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Immunization of Mice with Ultraviolet-Irradiated Schistosoma Mansoni Cercariae: A Re-Evaluation^*

David A. Dean, K. Darwin Murrell, Xu Shoutai AND Beverly L. Mangold

Naval Medical Research Institute, Bethesda, Maryland 20814
Animal Parasitology Institute, U.S. Department of Agriculture, Beltsville, Maryland 20705
The Shanghai Laboratory of Animal Schistosomiasis, The Chinese Academy of Agricultural Science, Shanghai, People's Republic of China

Mice immunized by percutaneous exposure to ultraviolet-irradiated Schistosoma mansoni cercariae developed levels of resistance to subsequent S. mansoni infection comparable to those induced by gamma-irradiated cercariae (50–70% reduction in adult worm burden). Cercariae treated with ultraviolet doses ranging from one to three times the minimum dose required to prevent long-term survival induced the highest levels of resistance.

Accepted for publication November 18, 1982.

^* This work was supported by the Naval Medical Research and Development Command, Work Unit No. MR041.05.01.0023) and the Office of Naval Research Contract No. N00014-81-C-0552. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the U.S. Navy Department or the naval service at large. The experiments reported herein were conducted according to the principles set forth in the current edition of the Guide for the Care and Use of Laboratory Animals, Institute of Laboratory Animal Resources, National Research Council.