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Autoradiographic Analysis of Schistosoma Mansoni Migration from Skin to Lungs in Naive Mice

Evidence That Most Attrition Occurs After the Skin Phase^*

A study was performed to determine the extent of attrition of Schistosoma mansoni in naive mice (innate resistance) during the 1st week of infection. Each mouse was exposed to exactly 50 cercariae radiolabeled with [⁷⁵Se] selenomethionine. On 1, 4, and 7 days postexposure, skin, lungs and liver were analyzed by compressed organ autoradiography for the presence of labeled larvae. Using this technique it was determined that no more than one-third of the 59% attribution that occurred between the cercarial and adult worm stages could be attributed to losses during the skin phase; most of the attrition in naive mice occurred after the migration of larvae to the lungs.

Accepted for publication December 10, 1982.

^* This work was supported by the Naval Medical Research and Development Command, Work Unit Nos. MR000.01.01.1267 and MR041.05.01.0023, and the Office of Naval Research Contract No. N00014-81-C-0552.

The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the U.S. Navy Department or the naval service at large.

The experiments reported herein were conducted according to the principles set forth in the current edition of the Guide for the Care and Use of Laboratory Animals, Institute of Laboratory Animal Resources, National Research Council.