AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 32(4), 1983, pp. 682-684
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

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In Vitro Cultivation of the Exoerythrocytic Stage of Plasmodium Berghei in a Hepatoma Cell Line

Michael R. Hollingdale*, Pamela Leland* AND Alan L. Schwartz{dagger}
* Biomedical Research Institute, 12111 Parklawn Drive, Rockville, Maryland 20852
{dagger} Division of Pediatric Hematology-Oncology, Children's Hospital Medical Center, Sidney Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of the exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.

Accepted for publication November 19, 1982.




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Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.