HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Colley, D. G. Articles by Freeman, G. L. Search for Related Content PubMed PubMed Citation Articles by Colley, D. G. Articles by Freeman, G. L., Jr.

Differences in Adult Schistosoma Mansoni worm Burden Requirements for the Establishment of Resistance to Reinfection in Inbred Mice

II. C57BL/KsJ, SWR/J, SJL/J, BALB/cAnN, DBA/2N, A/J, B10.A(3R), and B10.A(5R) Mice^*

Eight strains of mice (C57BL/KsJ, SWR/J, SJL/J, BALB/cAnN, DBA/2N, A/J, B10.A(3R), and B10.A(5R) were studied in regard to the development of resistance to secondary challenge with Schistosoma mansoni following a primary infection. Also analyzed were the number of eggs recoverable from the livers of these strains after primary infection and the size of the hepatic, schistosome egg-focused granulomas newly formed at various times after infection. As previously observed by us and others, most often the degree of resistance conferred by an acute primary infection is related to the number of adult worms harbored due to the initial infection. The mean levels of protection observed in the different strains were seen to cover a spectrum from moderate to strong resistance, rather than demonstrating high or low resistance strains. There was no observable effect of the major histocompatibility complex on this resistance state. The number of eggs recoverable from the livers of the various strains was calculated on a total liver, per female worm basis, and was seen to be less in C57BL/KsJ, SWR/J and SJL/J mice. Granulomatous reactivity also varied considerably in a strain-dependent manner. These data are compared with previously reported strain differences in S. mansoni infections. Although some similarities are observed between laboratories certain strain-related discrepancies also exist and are discussed.

Accepted for publication August 27, 1982.

^* This work was primarily supported by a grant from The Edna McConnell Clark Foundation (Grant No. 278-0063) and the Veterans Administration.

Address reprint requests to: Dr. Daniel G. Colley, Veterans Administration Medical Center, ACRE Building—Room 324, Nashville, Tennessee 37203.

This article has been cited by other articles:

				P. B. Bartley, A. Glanfield, Y. Li, D. I. Stanisic, M. Duke, M. K. Jones, and D. P. McManus Artemether Treatment of Prepatent Schistosoma japonicum Induces Resistance to Reinfection in Association with Reduced Pathology Am J Trop Med Hyg, June 1, 2008; 78(6): 929 - 935. [Abstract] [Full Text] [PDF]