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In Vitro Study of Drug Sensitivity of Plasmodium Falciparum: Evaluation of a New Semi-Micro Test^*

A modification of Rieckmann's microtechnique was used to determine the drug sensitivity of Plasmodium falciparum. The technique was found to be reliable and adequately sensitive with either blood from a malarial patient or strains of P. falciparum from in vitro continuous culture, with a success rate of 50%. Minor variations in the method had little influence on the results. Inhibition of maturation of parasites was compared with the inhibition of increase in parasitemia.

Accepted for publication July 7, 1982.

^* Address reprint requests to: Dr. J. Le Bras, Laboratoire de Parasitologie, Institut de Médecine et d'Epidémiologie Tropicales, Hôpital Claude Bernard, 10 avenue de la Porte d'Aubervilliers, 75019 Paris, France.

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