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Junin Virus Infection of Callithrix Jacchus: Pathologic Features^*

Pedro H. González, Rubén P. Laguens, Marcelo J. Frigerio, Miguel A. Calello AND Mercedes C. Weissenbacher

Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by immunofluorescent methods. With the exception of central nervous system damage, the morphological features and immunohistochemical and viral findings were similar to those recorded in human Argentine hemorrhagic fever.

Accepted for publication June 16, 1982.

^* This work was supported by grants from the Subsecretaría de Estado de Ciencia y Tecnología (SUBCYT), and Fundación Emilio Ocampo, Argentina.

Address reprint requests to: Dr. Pedro H. González, Cátedra de Patologiá II, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata, 1900, Argentina.

Members of Research Career from CONICET, Argentina.