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Am. J. Trop. Med. Hyg., 32(2), 1983, pp. 316-325
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

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Liver Collagen-Type Characterization in Human Schistosomiasis

A Histological, Ultrastructural, and Immunocytochemical Correlation*

Luis Biempica, Michael A. Dunn, Ismail A. Kamel, Refaat Kamel, Penelope K. Hait, Cynthia Fleischner, Stella L. Biempica, Catherine H. Wu AND Marcos Rojkind{dagger}
Liver Research Center and Departments of Pathology, Medicine, and Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, Liver Unit, Ain Shams University Faculty of Medicine, Cairo, Egypt, Department of Pathology, Cairo University Faculty of Medicine, Cairo, Egypt, and Biomedical Research Center for Infectious Diseases, Egyptian Ministry of Health, Cairo, Egypt

Liver biopsies of four patients with hepatosplenic schistosomiasis, two patients with schistosomiasis and chronic active hepatitis, two patients with chronic active hepatitis and four control patients with no clinical evidence of either disease, were examined by standard light microscopic techniques, electron microscopy and immunocytochemical staining for collagen type I, III and B. Pure schistosomiasis showed the classical "clay-pipe stem fibrosis" and granulomata composed of eosinophils, macrophages and lymphocytes. In that group, the hepatocellular damage was less conspicuous than in the groups with chronic hepatitis and was usually confined to the granulomatous or fibrotic areas. Destruction of the normal architecture and infiltration by macrophages and lymphocytes with severe damage of hepatocytes was found only in the cases of chronic active hepatitis, with or without associated schistosomiasis. Increased collagen deposits were demonstrated in all three groups. Types I, III and B were found in the enlarged portal triads and fibrotic septa. The intranodular or intralobular collagen stained negatively for type I and strongly positive for types III and B.

Accepted for publication June 30, 1982.


* Supported by Liver Research Center Grant AM 17702 from the National Institutes of Health.

Address reprint requests to: Dr. Luis Biempica, Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461.


{dagger} Present address: Department of Biochemistry, Centro de Investigación y de Estudios Avanzados, I.P.N., Apartado Postal 14-740, Mexico 14, D.F., Mexico.






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Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.