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Am. J. Trop. Med. Hyg., 32(2), 1983, pp. 277-285
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

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Late Metastatic Leishmaniasis in the Mouse

A Model for Mucocutaneous Disease*

A. Barral{dagger}, E. A. Petersen, D. L. Sacks AND F. A. Neva
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, and Department of Medicine, University of Arizona, Tucson, Arizona 85724

BALB/c, C57Bl/6 and (BALB/c x C57Bl/6)F1 mice all proved susceptible to infection by a strain of Leishmania isolated from a Central Brazilian with espundia. The course of disease differed markedly between BALB/c and C57Bl/6 mice. BALB/c mice suffered from a rapidly progressive and widely metastatic, but non-ulcerative, disease resembling diffuse cutaneous leishmaniasis. In contrast, C57Bl/6 mice initially contained parasite multiplication effectively and appeared clinically cured. However, the parasite could persistently be cultured up to about 1 year post-infection. At that time, the parasite load in the infected footpad increased and a patent disease developed characterized by distinctive ulcerative metastases with destruction of soft-tissue in the nasal region similar to the one observed in espundia. Development of disease in both strains of mice was associated with depression of cell-mediated immunity as monitored by delayed-type hypersensitivity in vivo and lymphocyte transformation in vitro. Thus, our study suggests that diffuse cutaneous leishmaniasis and espundia can be caused by the same strain of parasite, and that the particular clinical expression in the individual mouse is determined by the host response.

Accepted for publication July 16, 1982.


* Address reprint requests to: Eskild A. Petersen, Department of Internal Medicine, Section of Infectious Disease, Arizona Health Sciences Center, Tucson, Arizona 85724.


{dagger} Present address: Centro de Pesquizas gonçalo Mohiz, Rua Valdemar Falcão, 121-Brotas, 40.000 Salvador-Bahia, Brazil.






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Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.