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Am. J. Trop. Med. Hyg., 32(2), 1983, pp. 212-216
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

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Malaria at San Lazaro Hospital, Manila, Philippines, 1979–1981*

Richard L. Buck, Alberto K. Alcantara, Cesar V. Uylangco AND John H. Cross
U.S. Naval Medical Research Unit Number Two, APO San Francisco, California 96528, and San Lazaro Hospital, Manila, Republic of the Philippines

Results are presented from the 1,000 slide-confirmed malaria cases seen during the period August 1979–September 1981 at San Lazaro Hospital, in Manila, Philippines; 56% were caused by Plasmodium falciparum, 38% by P. vivax, 6% were mixed infections, and 0.1% by P. malariae. The overall case fatality rate was 1%, all due to P. falciparum. Cerebral involvement occurred in 7% and the case fatality rate was 20% compared to a case fatality rate of 0.2% among P. falciparum cases without cerebral involvement. In vivo chloroquine-resistant P. falciparum was seen in 4% of the cases, but of those treated in 1981, 9% of the cases showed resistance. The distribution of chloroquine-resistant cases by province in the Philippines is shown, with resistance being reported for the first time from Isabela, Bulacan, Zambales, Rizal and Bataan provinces. Diagnostic, clinical, and epidemiologic aspects of the cases are discussed, as well as the trend in malaria cases over the last 20 years.

Accepted for publication August 16, 1982.


* This study was supported through funds provided by the Philippine Ministry of Health and of the Naval Medical Research and Development Command, Navy Department for Work Unit MR041.09.01-0168.

The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Philippine Ministry of Health, the U.S. Navy Department or the U.S. Naval Service at large.

Address reprint requests to: Publications Office, U.S. Naval Medical Research Unit No. 2, APO San Francisco, California 96528.






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Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.