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Am. J. Trop. Med. Hyg., 32(1), 1983, pp. 6-10
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

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A Microassay for Detecting Merozoite Inhibition Suitable for Routine Laboratory use*

Neil Cowen, Robert Clancy, Allan Cripps AND Michael Alpers
Department of Pathology, Faculty of Medicine, The University of Newcastle and Hunter Immunology Unit, Royal Newcastle Hospital, Newcastle, NSW, Australia, and Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

A micro semiautomative assay of merozoite inhibition antibody has been developed, based on incorporation of radiolabeled isoleucine into parasite protein. The assay has been validated using 44 sera from healthy blood donors in Madang. Inhibition of uptake of label occurred in 43.2% of tests, while an enhancement of uptake was demonstrated in 4.7%. This assay has ‘potential’ for both seroepidemiological studies, and for providing a mechanism of biotyping wild isolates.

Accepted for publication May 20, 1982.


* This investigation received financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, under the Scientific Working Group on the Immunology of Malaria, TDR.






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Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.