AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 32(1), 1983, pp. 46-50
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walton, B. C.
Right arrow Articles by Neal, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walton, B. C.
Right arrow Articles by Neal, R. A.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*ALLOPURINOL
Medline Plus Health Information
*Leishmaniasis

Effectiveness of Allopurinol against Leishmania Braziliensis Panamensis in Aotus Trivirgatus

Bryce C. Walton*, James Harper, III{dagger} AND Ralph A. Neal
Gorgas Memorial Laboratory, Apartado 6991, Panamá 5, Republic of Panamá, and Protozoology Department, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, United Kingdom

Orally administered allopurinol at 50 mg/kg for 21 days showed pronounced antileishmanial activity against experimentally induced lesions of Leishmania braziliensis panamensis on the nose of Panamanian Aotus trivirgatus monkeys, with complete healing in 4 of 5, although parasitologic cure was achieved in only 2 of 5. The same total daily dose of drug, given in a divided dose twice daily, resulted in complete healing in all 5, and parasitologic cure in 4 of 5 animals. Standard treatment controls receiving 40 mg/kg of antimony stibogluconate intramuscularly for 15 days showed healing in 4 of 5 monkeys. It is not known if a similar level of effectiveness would result with this dose of allopurinol in humans, since Aotus may have a different pattern of metabolic conversion of the drug to the more active riboside.

Accepted for publication May 6, 1982.


* Pan American Health Organization/Adjunct Associate Gorgas Memorial Laboratory. Present address: Trypanosomiases and Leishmaniases, Parasitic Diseases Programme, World Health Organization, 1211 Geneva 27, Switzerland.


{dagger} Present address: Infectious Disease Branch, National Institute of Neurologic and Communicative Disorders and Stroke, National Institutes of Health, USDHHS, Bethesda, Maryland 20205.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.