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Am. J. Trop. Med. Hyg., 32(1), 1983, pp. 154-156
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene

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Original Antigenic Sin in Dengue

Scott B. Halstead, Suntharee Rojanasuphot AND Nadhirat Sangkawibha
Department of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, 3675 Kilauea Avenue, Honolulu, Hawaii 96816, and Virus Research Institute, Department of Medical Sciences, Ministry of Public Health, Bangkok, Thailand

Sequential blood samples were obtained from eight Thai children before, during and 3–5 months after hospitalization for dengue shock syndrome. All patients experienced a secondary-type antibody response as evidenced by hemagglutination-inhibition antibody responses in acute and convalescent sera. Dengue 2 viruses were recovered from two patients. In their pre-illness blood sample, all children had monotypic neutralizing antibodies; five to dengue 1, two to dengue 3 and one to dengue 4. The highest neutralizing antibody titers in acute phase and late convalescent sera were to the initial infecting virus type. This report documents for sequential dengue infections the existence of an original antigenic sin antibody response. It may be possible to apply this phenomenon to identify initial dengue serotype infection in individuals experiencing secondary dengue infections, thus helping to clarify the antecedents to dengue shock syndrome.

Accepted for publication June 10, 1982.




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Copyright © 1983 by the American Society of Tropical Medicine and Hygiene.