HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by White, N. J. Articles by Harinasuta, T. Search for Related Content PubMed PubMed Citation Articles by White, N. J. Articles by Harinasuta, T.

Quinine Loading Dose in Cerebral Malaria^*

In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.

Accepted for publication June 16, 1982.

^* This study was part of the Wellcome-Mahidol University, Oxford Tropical Medicine Research Programme funded by the Wellcome Trust of Great Britain.

Address reprint requests to: Dr. David A. Warrell, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 4, Thailand.

This article has been cited by other articles:

				N. Day and A. M. Dondorp The Management of Patients with Severe Malaria Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 29 - 35. [Abstract] [Full Text] [PDF]

				G. Pasvol The treatment of complicated and severe malaria Br. Med. Bull., February 22, 2006; 75-76(1): 29 - 47. [Abstract] [Full Text] [PDF]

				C. Wambebe, E. Sokomba, and G. J. Amabeoku Some behavioural effects of quinine in mice J Psychopharmacol, January 1, 1989; 3(3): 156 - 168. [Abstract] [PDF]