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Am. J. Trop. Med. Hyg., 31(6), 1982, pp. 1291-1293
Copyright © 1982 by The American Society of Tropical Medicine and Hygiene

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*Malaria

Demonstration of Hypnozoites in Sporozoite-Transmitted Plasmodium vivax Infection*

W. A. Krotoski, W. E. Collins, R. S. Bray{dagger}, P. C. C. Garnham{ddagger}, F. B. Cogswell, R. W. Gwadz, R. Killick-Kendrick{dagger}, R. Wolf, R. Sinden, L. C. Koontz AND P. S. Stanfill
Laboratory Research Branch, National Hansen's Disease Center, Carville, Louisiana 70721 Department of Tropical Medicine and Medical Parasitology, Louisiana State University Medical Center, New Orelans, Louisiana 70112 Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333 Department of Pure and Applied Biology, Imperial College at Silwood Park, Ascot, Berkshire SL5 7PY, England Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, and Delta Regional Primate Research Center (Tulane University), Covington, Louisiana 70433

Abstract. Hypnozoites of two strains of the human relapsing malaria parasite, Plasmodium vivax, have been detected among maturing 7- and 10-day pre-erythrocytic schizonts in liver biopsies of chimpanzees infected by intravenous inoculation of sporozoites obtained from dissected salivary glands of heavily infected anopheline mosquitoes. As in the simian relapsing species, P. cynomolgi, the hypnozoites of P. vivax at 7 and 10 days are uninucleate forms of approximately 4–5 µm diameter, lying within the cytoplasm of individual hepatocytes. Their presence in this relapsing human species is added support for the hypnozoite theory of malarial relapse.

Accepted for publication July 28, 1982.


* This investigation received financial support from the Special Programme for Research and Training in Tropical Diseases of the World Health Organization.


{dagger} Member, External Staff, Medical Research Council, England.


{ddagger} Senior Fellow Emeritus, Department of Pure and Applied Biology, Imperial College at Silwood Park.




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Copyright © 1982 by the American Society of Tropical Medicine and Hygiene.