AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 31(6), 1982, pp. 1164-1167
Copyright © 1982 by The American Society of Tropical Medicine and Hygiene

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Oxamniquine versus Niridazole for Treatment of Uncomplicated Schistosoma mansoni Infection*

M. E. Kilpatrick, N. A. El Masry, S. Bassily AND Z. Farid
U.S. Naval Medical Research Unit No. 3 (NAMRU-3), FPO, New York 09527/0007

Abstract. One hundred sixteen male patients with uncomplicated Schistosoma mansoni infection were randomized to treatment with oxamniquine (20 mg/kg a day for 3 days) or niridazole (15 mg/kg a day for 8 days) in an in-hospital study. Fifty-four patients were treated with oxamniquine; no serious drug side effects were noted. Twenty-six percent of children 16 years old and younger were cured, while 85% of adults were cured. Egg reduction was 89%. Sixty-two patients were treated with niridazole; four patients (one child and three adults) had serious side effects which necessitated discontinuing the drug. Seventy-one percent of children and 84% of adults were cured. Egg reduction was 84%. Minor clinical side effects occurred during therapy with both drugs (26% with oxamniquine, 48% with niridazole) but cleared after completion of therapy. Niridazole is the more effective drug for the child with uncomplicated Schistosomiasis mansoni, but oxamniquine is advised for the adult with this disease.

Accepted for publication April 22, 1982.


* Supported by Naval Medical Research and Development Command, NNMC, Bethesda, Maryland Work Unit Ns. 63706N M0095PN.002-5062.

The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy or the Egyptian Ministry of Health.

Address reprint requests to: Research Publication Division, U.S. NAMRU-3, FPO New York 09527/0007.






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Copyright © 1982 by the American Society of Tropical Medicine and Hygiene.