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An Onchocercal Nodule Appearing during Diethylcarbamazine Therapy^*

Eric S. Boye AND Daniel H. Connor

Abstract. We describe the appearance of an onchocercal nodule in a patient during treatment with diethylcarbamazine (DEC). This is a unique occurrence. DEC has been employed in the treatment of onchocerciasis for many years, but there have been no reports of any effects of DEC on nodules. Histopathological studies in which nodules have been examined before and after treatment of patients with DEC have not revealed any changes induced by such treatment. The histological appearance of this nodule is described, and the probable mechanism of its enlargement is discussed.

Accepted for publication April 7, 1982.

^* The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Address reprint requests to: Daniel H. Connor, M.D., Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306.

Research Fellow, World Health Organization, currently assigned to WHO Reference Laboratory for Filarial Infections of Man, at the Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology.