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Am. J. Trop. Med. Hyg., 31(5), 1982, pp. 934-941
Copyright © 1982 by The American Society of Tropical Medicine and Hygiene

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Muscle Sarcoplasmic Reticulum Antigen Shared by a Trypanosoma Cruzi Clone*

Moyses Sadigursky{dagger}, Alberto M. Acosta AND Charles A. Santos-Buch
Department of Pathology, Cornell University Medical College, New York, New York 10021

The results reported here show that a clone of a South American Trypanosoma cruzi human isolate has an epitope antigenically related to sarcoplasmic reticulum adenosine triphosphatase preparations (SRA), an enzyme implicated in the contraction-relaxation cycle of striated muscle. The antigenic determinant of T. cruzi, which is cross-reactive with SRA, is located in the interior of the parasite. No surface cross-reaction was detected with intact, freely swimming flagellates. Indeed, the degree of cross-reactivity was increased when T. cruzi microsomes were trypsinized, probably resulting in further exposure of the normally internal cross-reactive epitope.

Accepted for publication January 18, 1982.


* Address reprint requests to: Dr. Charles A. Santos-Buch, Department of Pathology, The New York Hospital-Cornell University Medical College, 1300 York Avenue, New York, New York 10021.


{dagger} Dr. Sadigursky is a recipient of a Cornell-Bahia Program Fellowship from the Rockefeller Foundation.




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Copyright © 1982 by the American Society of Tropical Medicine and Hygiene.