AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 31(3), 1982, pp. 518-521
Copyright © 1982 by The American Society of Tropical Medicine and Hygiene

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Urinary Granulocyte Colony-Stimulating Factor in Bilharziasis*

Lotfy Abdel Naby Mahmoud, William A. Robinson AND Maureen A. Entringer
Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt, and Department of Medicine, Division of Medical Oncology, University of Colorado, Health Sciences Center, Denver, Colorado 80262

Studies have been done to determine the levels of human urinary granulocyte colony-stimulating factor in Egyptian patients with active bilharziasis. Colony-stimulating factor levels were measured by a semi-solid tissue culture colony assay with murine bone marrow as the target cell source. The levels in urine from patients with bilharziasis (mean 118) were found to be significantly elevated above control values found in normal human urine (mean 72) derived from the same population. This is the first demonstration of an effect of parasitic infection in man on the granulocyte regulatory system, and opens the way for future studies in this area.

Accepted for publication October 7, 1981.


* Supported by grants from the National Institutes of Health, National Cancer Institute (1R01CA23552-03) and American Cancer Society #CH-8K.

Address reprint requests to: Dr. William A. Robinson, Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262.






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Copyright © 1982 by the American Society of Tropical Medicine and Hygiene.