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Am. J. Trop. Med. Hyg., 31(3), 1982, pp. 438-440
Copyright © 1982 by The American Society of Tropical Medicine and Hygiene

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A Comparative Trial of Oral Chloroquine and Oral Co-Trimoxazole in Vivax Malaria in Children

Harbans Lal
Department of Pediatrics, Government Medical College, Patiala, India

Responses of parasitemia and fever in vivax malaria to standard doses of chloroquine and different dosage schedules of co-trimoxazole were compared in 165 children. Though both the drugs were effective, chloroquine was significantly faster in clearing parasitemia than all the dosage schedules of co-trimoxazole. No statistically significant difference was observed in rapidity of defervescence between chloroquine and the two high daily dosage regimens of co-trimoxazole. Gastrointestinal intolerance was persistantly higher with chloroquine. Asymptomatic sulphonamide crystalluria was seen in a large number of cases receiving the two high daily dosage schedules of co-trimoxazole.

Accepted for publication November 30, 1981.






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Copyright © 1982 by the American Society of Tropical Medicine and Hygiene.