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Japanese Encephalitis Vaccine (2–8 Strain) and Parent (SA 14 Strain) Viruses in Culex Tritaeniorhynchus Mosquitoes^*

The Japanese encephalitis vaccine virus (JE 2–8) and its parent virus (JE SA 14) strains were compared for their ability to infect, to replicate in, and to be transmitted by Culex tritaeniorhynchus mosquitoes. Both viruses replicated in the mosquitoes after intrathoracic infection. The JE 2–8 vaccine was transmitted to 1/36 (3%) of suckling mice bitten by intrathoracically infected mosquitoes; however, the parent JE SA 14 strain was transmitted to 46/46 (100%) of the mice bitten. In oral infection trials, only 4/36 (11%) of the Cx. tritaeniorhynchus mosquitoes ingesting the vaccine JE 2–8 strain became infected, whereas 19/19 (100%) of those ingesting the parent JE SA 14 strain became infected. The vaccine JE 2–8 strain did not revert to virulence during passage in mosquitoes.

Accepted for publication July 31, 1981.

^* This project was supported in part by grants AI 11132 and AI 10984 from the National Institutes of Health and DADA contracts 17-79-C9094 and 17-72-C-2170 from the U.S. Army Medical Research and Development Command and N00014-78-C-0104 from the U.S. Naval Medical Research Development Command.

Address reprint requests to: Barry J. Beaty, Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, 60 College Street, Box 3333, New Haven, CT 06510.

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