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Enzyme-Linked Immunosorbent Assay (Elisa) for the Detection of Antibody to Cysticerci of Taenia Solium

Arwin R. Diwan^*,,, Millicent Coker-Vann^*, Paul Brown^*, D. B. Subianto^*,,, R. Yolken, R. Desowitz, A. Escobar^||, Clarence J. Gibbs, Jr.^* AND D. Carleton Gajdusek^*

^* Laboratory of Central Nervous System Studies, NINCDS, National Institutes of Health, Bethesda, Maryland 20205,
Department of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, Honolulu, Hawaii 96816,
Public Health Department, Jayapura, Irian Jaya, Indonesia,
Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and
^|| Department of Neuropathology, Instituto Nacional de Neurologica y Neurocirugia, Mexico City, Mexico

An enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to cysticerci of Taenia solium has been developed that employs a pork muscle antigen control for the cysticercus test antigen, somewhat improving the serological distinction between infected and uninfected subjects. Serum antibody to cysticercus was detected in 79% of classical neurocysticercosis patients from Mexico, and in 61% of a group of cysticercosis patients with an unusually rapid invasion of the central nervous system in an endemic focus of disease in Irian Jaya. Antibody was absent in a group of healthy American laboratory personnel, and in residents of a non-endemic region of Papua New Guinea. Additional tests on sera from patients with other parasitic diseases showed that cross-reactivity may occur in some patients with schistosomiasis, echinococcosis, and possibly angiostrongyliasis; however, these parasites are not known to cause human infection in Irian Jaya.

Accepted for publication August 27, 1981.