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Am. J. Trop. Med. Hyg., 31(2), 1982, pp. 297-301
Copyright © 1982 by The American Society of Tropical Medicine and Hygiene

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Complement-Mediated Adherence of Cells to Microfilariae of Brugia Malayi*

Willy F. Piessens AND Wilmar Dias Da Silva{dagger}
Department of Medicine, Harvard Medical School, and Department of Rheumatology and Immunology, Brigham and Women's Hospital, and the Center for Blood Research, Boston, Massachusetts 02115

Immune sera promote the adherence of human buffy coat cells to microfilariae of Brugia malayi. This effect is augmented by the simultaneous addition of fresh human or guinea pig serum. The heat-labile, adherence-promoting factor present in nonimmune sera appears to be complement. In the absence of antibody, microfilariae activate complement via the alternative pathway and C3 is deposited on the microfilarial sheath.

Accepted for publication September 16, 1981.


* This work was supported by U.S. Public Health Grants AI 16479-01 and AI 14157, by the Filariasis Component of the United Nations Development Programme-World Bank-World Health Organization Special Programme for Research and Training in Tropical Diseases and by the Rockefeller Foundation.

Materials for this study were provided by the U.S.-Japan Cooperative Medical Science Program, National Institutes of Health, Bethesda, Maryland.


{dagger} Present address: Departménto de Immunologia e Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Address reprint requests to: Dr. W. F. Piessens, Seeley G. Mudd Building, Room 507, 250 Longwood Avenue, Boston, MA 02115.






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Copyright © 1982 by the American Society of Tropical Medicine and Hygiene.