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Brugia Malayi Microfilariae from the Peritoneal Cavity of Jirds Vary in Their Ability to Penetrate the Mosquito Midgut^*

A. Faye Schrater, Philippe A. Rossignol, Bruce Hamill, Willy F. Piessens AND Andrew Spielman

Department of Medicine, Harvard Medical School and Department of Rheumatology and Immunology, Brigham and Women's Hospital
Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts 02115

Development in mosquitoes of Brugia malayi microfilariae obtained from the blood of jirds was compared to that of microfilariae from the peritoneal cavity. Penetration of the mosquito midgut wall as well as development into third-stage larvae was assessed. About 70% of blood-borne microfilariae penetrated the midgut wall whether ingested directly from a microfilaremic jird or from a membrane feeder containing blood from the same donor. In contrast, less than 30% of microfilariae from the peritoneal cavity penetrated the midgut wall. Microfilariae in the peritoneal cavity of jirds vary in ability to penetrate the midgut of mosquitoes; some penetrate as rapidly as do blood-borne microfilariae, others penetrate more slowly, and most fail to penetrate the midgut. Regardless of origin, microfilariae that penetrated the midgut wall developed into third-stage larvae.

Accepted for publication September 24, 1981.

^* This work was supported by grant #AI-16479 from the National Institutes of Health, grant No. RF 80019 from the Rockefeller Foundation, and contract No. DAMD 17-78-C-8026 from the U.S. Army Medical Research and Development Command.

Address reprint requests to: Dr. A. F. Schrater, Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115.