HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Andrade, Z. A. Articles by de Brito, P. A. Search for Related Content PubMed PubMed Citation Articles by Andrade, Z. A. Articles by de Brito, P. A.

Curative Chemotherapy and Resistance to Reinfection in Murine Schistosomiasis^*

Complete parasitological cure was obtained by specific chemotherapy in mice with a 10-week-old infection induced by inoculating 30 cercariae of Schistosoma mansoni. By challenging the cured animals with 100 cercariae it was found that cutaneous and pulmonary reactivity to invading schistosomula, the ability to modulate periovular granulomas in the liver, and the resistance to reinfection, as measured by survival rates and recovery of worms from the portal vein system, persisted for 1 and 2 months following treatment and disappeared after 6 months. Thus, a residual immunity and reactivity to reinfection seems to persist in the host for some time after curative chemotherapy of schistosomiasis.

Accepted for publication June 1, 1981.

^* Supported by a grant (PDE 01-2-05) from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil.