AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 31(1), 1982, pp. 1-9
Copyright © 1982 by The American Society of Tropical Medicine and Hygiene

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Sulfadoxine-Pyrimethamine for the Treatment of Acute Malaria in Children in Papua New Guinea

I. Plasmodium falciparum

Brian Darlow*, Helena Vrbova, Sean Gibney, Damien Jolley, John Stace AND Michael Alpers
Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea, and Madang General Hospital, Madang, Papua New Guinea

Chloroquine-resistant Plasmodium falciparum malaria is increasing in prevelance in Papua New Guinea and alternative therapies for acute malaria are being sought. A trial of sulfadoxine-pyrimethamine for the treatment of acute falciparum malaria in children has been carried out in Madang, Papua New Guinea. Eighty-five children were treated with sulfadoxine-pyrimethamine, either alone or in combination with a single 10 mg/kg dose of chloroquine. Of 78 children completing 28-days follow-up, treatment failures occurred in 15 (19.2%) and of these, 8 (10.3%), are believed to be sulfadoxine-pyrimethamine resistant; the others remain equivocal. There was no advantage in this study in combining a single dose of chloroquine with sulfadoxine-pyrimethamine; indeed, this combination was associated with an increased incidence of vomiting. It is argued that sulfadoxine-pyrimethamine should not become the standard presumptive treatment for acute malaria in Papua New Guinea.

Accepted for publication March 28, 1981.


* Present address: Department of Paediatrics, Christchurch Hospital, Private Bag, Christchurch, New Zealand.




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J. Marfurt, I. Mueller, A. Sie, P. Maku, M. Goroti, J. C. Reeder, H.-P. Beck, and B. Genton
Low Efficacy of Amodiaquine or Chloroquine Plus Sulfadoxine-Pyrimethamine against Plasmodium falciparum and P. vivax Malaria in Papua New Guinea
Am J Trop Med Hyg, November 1, 2007; 77(5): 947 - 954.
[Abstract] [Full Text] [PDF]


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Copyright © 1982 by the American Society of Tropical Medicine and Hygiene.