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Am. J. Trop. Med. Hyg., 30(6), 1981, pp. 1342-1343
Copyright © 1981 by The American Society of Tropical Medicine and Hygiene

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Quinine alone versus Quinine Plus a Pyrimethamine-Sulfadoxine Combination in the Treatment of Plasmodium Faliciparum Cerebral Malaria*

Y. Naparstek, D. Weiler-Ravell, J. Shemer, D. Englehard, J. Sack, D. T. Spira AND J. Adler
Hadassah, University Hospital, Jerusalem, Chaim Shiba Medical Center, Tel Hashomer, and Shaare Zedek Hospital, Jerusalem, Israel

Fifty-two patients with severe chloroquine resistant Plasmodium falciparum malaria were treated in a randomized double blind study with either quinine and a single dose of pyrimethamine-sulfadoxine (Fansidar) or quinine alone. Although no statistically significant differences were observed, the 25 patients who received both drugs responded faster and had a more favorable outcome (no deaths) when compared to the 27 who received quinine alone (2 deaths).

Accepted for publication July 7, 1981.


* Address reprint requests to: Y. Naparstek, M. D., Department of Medicine A, Hadassah University Hospital, Jerusalem, Israel.







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Copyright © 1981 by the American Society of Tropical Medicine and Hygiene.