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Fifty-two patients with severe chloroquine resistant Plasmodium falciparum malaria were treated in a randomized double blind study with either quinine and a single dose of pyrimethamine-sulfadoxine (Fansidar) or quinine alone. Although no statistically significant differences were observed, the 25 patients who received both drugs responded faster and had a more favorable outcome (no deaths) when compared to the 27 who received quinine alone (2 deaths).
Accepted for publication July 7, 1981.
* Address reprint requests to: Y. Naparstek, M. D., Department of Medicine A, Hadassah University Hospital, Jerusalem, Israel.
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