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Am. J. Trop. Med. Hyg., 30(6), 1981, pp. 1198-1200
Copyright © 1981 by The American Society of Tropical Medicine and Hygiene

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Immunization of Mice with Trypanosoma Rhodesiense Exposed to Ultraviolet Irradiation

Yupin Charoenvit AND Gary H. Campbell
Division of Tropical and Geographic Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131

Exposure time of Trypanosoma rhodesiense as short as 1 minute to ultraviolet (U.V.) light prevents the organisms from causing infection. Live trypanosome challenge of mice immunized with U.V.-irradiated trypanosomes results in sterile immunity. This allows a method for the induction of protective immunity to experimental trypanosomiasis which can be performed in most laboratoires using U.V. germicidal lamps found in sterile hoods.

Accepted for publication March 7, 1981.






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Copyright © 1981 by the American Society of Tropical Medicine and Hygiene.