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Reaction of Immune Sera with Components of the Human Malarial Parasite, Plasmodium Falciparum^*

Robert T. Reese, Mary R. Motyl AND Renate Hofer-Warbinek

Human and monkey sera from individuals exposed to Plasmodium falciparum were characterized by indirect immunofluorescence, in vitro parasite growth inhibition, and immunoprecipitation of ¹²⁵I-labeled parasite antigens followed by analytical sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE). In general there was a good correlation between fluorescence titer and the ability of a serum to inhibit parasite growth in vitro. Exceptions were found, however. Some variance was seen in the ability of a given serum to inhibit different strains of the parasite. The significance of this is unknown. The proteins bound by human sera with high and low in vitro inhibitory capacities were compared by SDS-PAGE. The human sera which did not inhibit parasite growth in vitro well differed from those which did by failing to efficiently bind certain parasite components having molecular weights in the range of 200,000, 70,000–85,000, and 45,000.

Accepted for publication June 2, 1981.

^* This work was supported by NIH Grant AI-15468, U.S. Army Contract DAMD17-79-C-9207, AID Contract TA-C-1373, and a grant from the Camille and Henry Dreyfus Foundation.

Present address: Department of Molecular Immunology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California 92037. Send correspondence to this address.

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