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Changes in the Enteric Vasculature of Mice Infected with Schistosoma mansoni^*

B. A. Nagy, S. K. File AND J. H. Smith

Mesenteric and intestinal vasculature of mice infected with S. mansoni was injected transaortically with a silicone elastomer. The mesenteries and intestines were then cleared and examined with a stereomicroscope. Marked tortuosity and dilatation of mesenteric and intestinal veins and arteries were found to be confined to areas of oviposition and were associated with small arteriovenous shunts which were not present in control animals or areas of intestine devoid of eggs. These findings suggest that splanchnic arterial-portal venous shunts add a hyperkinetic component to intrahepatic portal venous obstruction and synergistically result in portal hypertension.

Accepted for publication December 28, 1980.

^* This study was supported by the James W. McLaughlin Fellowship Fund and DHEW Biomedical Research Support Grant 0-14544-88020.

Address reprint requests to: Jerome H. Smith, M.D., Pathoparasitology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77550.

Present address: Emory University School of Medicine, Atlanta, Georgia.