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Am. J. Trop. Med. Hyg., 30(5), 1981, pp. 952-954
Copyright © 1981 by The American Society of Tropical Medicine and Hygiene

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Resistance to Trypanosoma brucei in Mice Following Inoculation of NTG-Treated Trypanosomes*

Randy P. Johnson AND Lois Wong Chi
Department of Biological Science, California State University Dominguez Hills, School of Natural Sciences and Mathematics, Carson, California 90747

The alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (NTG) was tested as an attenuating agent for Trypanosoma brucei. Parasites were treated with 4 mcg/ml NTG and injected into mice at intervals of 7–14 days. Those mice surviving four injections of NTG-treated trypanosomes were later challenged and showed a 100% resistance to infection. A corresponding group of control mice showed a 6% resistance to infection.

Accepted for publication December 20, 1980.


* This study was supported in part by NIH MBS research grant RR08156-01.






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Copyright © 1981 by the American Society of Tropical Medicine and Hygiene.