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Am. J. Trop. Med. Hyg., 30(5), 1981, pp. 1106-1112
Copyright © 1981 by The American Society of Tropical Medicine and Hygiene

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*Hantavirus Infections

Intraspecific Transmission of Hantaan Virus, Etiologic Agent of Korean Hemorrhagic Fever, in the Rodent Apodemus agrarius

Ho Wang Lee, Pyung Woo Lee, Luck Ju Baek, Cheol Kun Song AND In Wha Seong
Department of Microbiology, Korea University College of Medicine, 4 Myungyun-Dong 2 Ga, Chongno-Ku, Seoul 110, Korea

Experimental parameters of infection and intraspecific transmission of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, in Apodemus agrarius rodents were determined. Mice inoculated by the intramuscular route experienced viremia for about 1 week beginning on day 7. After 3 weeks, immunofluorescent and neutralizing antibodies were present and no mouse ever developed signs of acute illness. Virus was recovered from lung, kidney, salivary gland, and liver, and virus excretion in urine, saliva, and feces occurred from about day 10 through day 360 (urine) post-inoculation. Antigen, but not infectious virus, was persistent in lung tissue for as long as 1 year. Horizontal contact infection occurred among cage-mates regardless of sexual pairing up to 360 days after infection and no evidence for participation of ectoparasitic arthropods in such transmission was obtained.

Accepted for publication January 10, 1981.




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Copyright © 1981 by the American Society of Tropical Medicine and Hygiene.